Expanding the frontiers of therapy

Treatment of rheumatoid arthritis (RA) has dramatically changed over the past decade, and much progress has been made in improving the prognosis of RA patients as a result of elaboration of novel treatment strategies and the development of biologic agents. Nevertheless, up to 50% of patients are either not controlled sufficiently or do not respond at all to current treatments, including biologicals. A better understanding of the background of these therapeutic limitations is required, but novel therapies that might help to reduce the residual and significant burden of the disease also represent future hopes.